Case Report: Rasmussen’s Encephalitis Treated Successfully with Rituximab
نویسندگان
چکیده
Rasmussen's encephalitis (RE), or chronic focal encephalitis, is a progressive neurologic condition consisting of cognitive regression, hemiparesis, and intractable epilepsy. While the etiology is unknown, evidence supports an autoimmune basis. Although steroids, plasmapheresis, and intravenous immunoglobulin (IVIg) may afford limited benefit, standard of care for pediatric cases typically involves hemispherectomy. In this report, we present a case of adult-onset Rasmussen's encephalitis with intractable epilepsy, ultimately responsive to a rituximab (Rituxan®) anti-B lymphocyte treatment protocol. Categories: Neurology, Internal Medicine
منابع مشابه
Adult onset Rasmussen’s encephalitis associated with reflex language induced seizures responsive to Rituximab therapy
Rasmussen’s encephalitis (RE) is a rare, focal and progressive inflammatory disorder of unknown aetiology, resulting in unilateral hemispheric atrophy, contralateral hemiparesis and hemianopia, dysphasia with language-dominant hemispheric involvement and intractable epilepsy. RE is associated with polymorphic seizure types including epilepsia partialis continua (EPC) [1]. Current treatment stra...
متن کاملRituximab used successfully in the treatment of anti-NMDA receptor encephalitis.
We report the case of a young woman with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis, without tumor, who was successfully treated with rituximab. Because conventional immunotherapy, including corticosteroids, immunoglobulin (IVIg), and plasma exchange showed little improvement in our patient, we introduced another treatment using rituximab. A week after the first administration of r...
متن کاملCombined Therapy for Anti-N-methyl D-aspartate Receptor Encephalitis
Background Anti-N-methyl- d-aspartate receptor (anti-NMDAR) encephalitis is an autoimmune neurological disorder that usually occurs as a paraneoplastic syndrome and is particularly associated with ovarian teratoma. Standard therapy for severe cases is not established and the prognosis in patients who do not respond to first-line treatment is poor. Case Report An 11-year-old boy complained ps...
متن کاملUncommon Complications of Herpes Simplex Encephalitis in a 7 Year Old Child in Iran: A Case Report
HSV-induced encephalitis is one of the most common viral encephalitis in children with known signs and symptoms, including personality changes, fever, impaired consciousness and focal neurological deficits. Imaging findings also include temporal lobe and fronto-orbital involvement. In the present study, we present a 7-year-old girl diagnosed with HSV1-induced herpes encephalitis with unusual sy...
متن کاملAutoimmune Encephalitis: A Case Presentation with Recurrent Febrile Seizures and Psychiatry Problems
Background: Autoimmune encephalitis is being diagnosed more and more often in the pediatric age group. It should be suspected in children with psychiatric symptoms, encephalopathy, abnormal movements or epileptic seizures. The most frequent autoimmune encephalitis in the pediatric is anti-N-methyl-D-aspartate (anti- NMDA) receptor encephalitis. Case report: We report a four-year-old boy with e...
متن کامل